منابع مشابه
p53: Pro-aging or pro-longevity?
continues to surprise biologists. For nearly a decade, it was thought to be an oncogene [1, 2], only to be subsequently declared a potent tumor suppressor [3, 4]. Initially characterized as a transcriptional activator, we now know p53 is also a transcriptional repressor [5]. And just as it seemed p53 activities were confined to the nucleus, it became apparent that p53 also functioned in the cyt...
متن کاملPremature and accelerated aging: HIV or HAART?
Highly active antiretroviral therapy (HAART) has significantly increased life expectancy of the human immunodeficiency virus (HIV)-positive population. Nevertheless, the average lifespan of HIV-patients remains shorter compared to uninfected individuals. Immunosenescence, a current explanation for this difference invokes heavily on viral stimulus despite HAART efficiency in viral suppression. W...
متن کاملAging and longevity genes.
The genetics of aging has made substantial strides in the past decade. This progress has been confined primarily to model organisms, such as filamentous fungi, yeast, nematodes, fruit flies, and mice, in which some thirty-five genes that determine life span have been cloned. These genes encode a wide array of cellular functions, indicating that there must be multiple mechanisms of aging. Nevert...
متن کاملAging: miRacles of Longevity?
The inventory of processes that miRNAs regulate has continued to expand since their relatively recent discovery. A new study reveals not only that the expression of miRNAs changes with age, but also that these miRNAs can act in both pro- and anti-longevity regulatory pathways.
متن کاملLongevity and aging
Research into the biology of aging seeks to understand the basic mechanisms of aging, with the goal of extending the period of life spent free from chronic disease and disability. Aging results from molecular processes that are modulated by genetic and environmental parameters. At least some of these mechanisms of aging are broadly shared across eukaryotic species from yeast to mice, and likely...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Brazilian Journal of Food Technology
سال: 2017
ISSN: 1981-6723
DOI: 10.1590/1981-6723.19416